Rheumatoid Arthritis Overview
With more than 200,000 cases in the US each year, Rheumatoid arthritis (RA) is a common, chronic inflammatory disorder that affects various joints including hands and feet. RA also classifies as an autoimmune disorder which means the immune system attacks healthy body tissues. Regular activities become increasingly difficult due to painful swelling from abrasive effects to the lining of joints which leads to joint deformity and bone erosion. Inflammation from RA also damages other parts of the well, and severe cases have caused physical disabilities .
Endocannabinoids and the Immune System
Research reveals both CB1 and CB2 receptors are found within immune cells which implies the major influence cannabinoids have with managing the immune system. The administration of cannabinoids, or the use of enzyme blockers to prevent decomposition of endocannabinoids, promotes immunosuppression and supports organ recovery from immune-mediated damages. Another benefit of cannabinoid use is its ability to suppress inflammatory reactions by deregulating cytokine production and enhancing T-regulatory cells .
Clinical reviews have concentrated on the potential of cannabinoids as an anti-inflammatory force against autoimmune and inflammatory diseases primarily prompt from cellular immune components. A particular study published that a daily oral administration of 5 mg of CBD subdued the progression of Rheumatoid arthritis. And further trials depict how manipulating endocannabinoids or issuing exogenous cannabinoids establishes potent treatment procedures for inflammatory disorders .