CBD for Alzheimer's Disease and Dementia | cbdMD

Alzheimer’s Disease

Alzheimer’s Disease Overview

A typical, progressive disease, Alzheimer’s damages memory and other vital mental functions. Common symptoms include confusion and memory loss as brain cells, and their connections deteriorate and eventually die. Alzheimer’s disease affects millions of people per year in the United States, and while there are medications and prescribed treatments, they usually offer to improve symptoms temporarily at best[74].

Beneficial Effects of CBD

Scientists find that using CBD for Alzheimer’s disease prevents hippocampal and cortical neurodegeneration; it’s also neuroprotective, reduces tau hyperphosphorylation, regulates microglial cell migration, and displays anti-inflammatory and antioxidant abilities. CBD was also documented to protect against neurotoxicity and microglial-activated neurotoxicity brought on by amyloid-β (Aβ) peptides, improve cell viability, and decrease Aβ production by activating amyloid precursor protein (APP) gene synthesis. Such discoveries imply that CBD is a prime form of treatment for pathologies associated with Alzheimer’s[75].

Case Developments

Published studies demonstrate the anti-inflammatory and neuroprotective effects of CBD using mammalian models in which mice were intrahippocampal injected with human Aβ42 and then treated daily with intraperitoneal injections of CBD [2]. Another case investigates the effects of CBD on cognition in a pharmacological model of Alzheimer’s disease which resulted in the reversal of cognitive deficits of mice treated with amyloid-β peptides[75].

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